| Autor: | Zanella, Louise, Riquelme, Ismael, Reyes, Maria Elena, Infante, Francisca, Reyes, Soledad, Ramirez, Eugenio, Ili, Carmen, Brebi, Priscilla |
| Revista: | Virus Research |
| Año: | 2022 |
| Número: | |
| Paginas: | 198687 |
| Volumen: | 311 |
| Abstract: | The human T cell lymphotropic virus type 1 (HTLV-1), unlike other RNA viruses such as HIV, has a stable genome and has infected humans since remote times. Although the HTLV-1 infection is endemic in South America, there is scarce information about HTLV-1 in Chile and its history of introduction. This study assessed the genomic content of HTLV-1 from Chile and its relationship with HTLV-1 lineages circulating worldwide by phylogenetic reconstruction and dating analyses. A total of 30 HTLV-1 genomes collected from the four continents were used to conduct dating analyses, including the first HTLV-1 genome from Amerindian/Mapuche ethnicity. Estimation was performed using a Bayesian Markov Chain Monte Carlo coalescent-based approach as implemented in the BEAST program. The time of the most recent ancestor of HTLV-1 from Chile was ?1409 years ago, which coincides with the period of Amerindian population expansion across South America. Our results suggest HTLV-1aA was possibly introduced in Chile during the migrations of the ancestral indigenous populations. |
| Idioma: | en |
| Base de Datos: | PubMed |
| Ver Más: | https://doi.org/10.1016/j.virusres.2022.198687 |