| Autor: | Diaz-Dinamarca, D. A., Soto, D. A., Leyton, Y. Y., Altamirano-Lagos, M. J., Avendaño, M. J., Kalergis, A. M., Vasquez, A. E. |
| Revista: | Molecular Immunology |
| Año: | 2018 |
| Número: | |
| Paginas: | 63-70 |
| Volumen: | 103 |
| Abstract: | The Surface Immunogenic Protein (SIP) of Group B Streptococcus (GBS) had been described as a good target for vaccine development. To date, SIP has been reported as a highly conserved protein, and in a mouse model it induces protection against lethal GBS challenge. Also, similar effects have been described by intranasal immunization with a SIP-based vaccine. In this study, we show the immune response induced by an oral SIP-based vaccine formulated on alum in a mouse model. Our vaccine can reduce vaginal GBS colonization and induce specific SIP-antibodies with opsonophagocytosis activities against GBS. Moreover, we observed the activation of T-cells producing IFN-?, TNF-?, IL-10, IL-2, and increased expression of the transcription factor T-bet, suggesting a Th1-type humoral response. The oral SIP-based vaccine is a novel alternative in the development of a vaccine against GBS. |
| Idioma: | eng |
| Base de Datos: | PubMed |
| Ver Más: | http://www.ncbi.nlm.nih.gov/pubmed/30205305 |